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Targeted Protein Degradation & PROTACs

Design bifunctional degraders (PROTACs) and molecular glues that hijack the ubiquitin-proteasome system to remove disease-driving proteins instead of merely inhibiting them.

PROTACmolecular glueE3 ligaseCRBN
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Default learning track

4 phases · ~16–22 weeks

A baseline path through this sector with milestones, prerequisites, and concrete projects. Click Personalize this roadmap above to have the AI tailor pace, depth, and resources to your background and goals.

1

Phase 1 — Foundations

3–4 weeks 30–40 hours

Build the conceptual and quantitative base needed to read papers and follow tutorials in the sector.

Prerequisites

  • Comfortable with basic biology / health-science vocabulary
  • Ability to install software and use a terminal

Skills you'll build

Python or R basicsLinux shellGit/GitHubReading scientific literature

Hands-on projects

Reproducible analysis notebook

Walk through a published tutorial in RDKit + PyMOL + PROTAC-DB and reproduce its results on the provided sample data.

Deliverable: GitHub repo with a Jupyter/Quarto notebook, environment.yml, and README

Milestones

  • Set up reproducible Conda/Mamba environment and a public GitHub repo
  • Read and summarize 3 review papers covering the sector landscape
  • Complete an intro statistics or scripting course end-to-end
Citation · course
Coursera · Drug Development Product Management
UC San Diego
Why: Category match (Pharma & Biotech R&D)
2

Phase 2 — Core tools & datasets

4–6 weeks 60–80 hours

Learn the standard analytical stack of the sector and the canonical public datasets used by professionals.

Prerequisites

  • Completed Phase 1 reproducible notebook
  • Working Python/R environment

Skills you'll build

RDKit + PyMOL + PROTAC-DBData wranglingQC & exploratory analysisVersion-controlled pipelines

Hands-on projects

Dataset deep-dive on PROTAC-DB + ChEMBL degrader sets

Pick one study from PROTAC-DB + ChEMBL degrader sets, reproduce the headline result, and write a short technical note on what you found.

Deliverable: GitHub repo + 3-page PDF write-up

Milestones

  • Run the official RDKit + PyMOL + PROTAC-DB tutorial end-to-end on real data
  • Download and explore one full dataset from PROTAC-DB + ChEMBL degrader sets
  • Document a clean QC + analysis pipeline that another person could rerun
Citation · training
FDA Learn portal
U.S. FDA
Why: Category match (Pharma & Biotech R&D)
3

Phase 3 — Applied projects

6–8 weeks 80–120 hours

Move from tutorials to original analyses on real questions. Start showing your work publicly.

Prerequisites

  • Phase 2 dataset deep-dive complete
  • Comfortable with the sector's primary tooling

Skills you'll build

End-to-end pipeline designStatistical interpretationScientific writingReproducible reports

Hands-on projects

PROTAC design exercise

Pick a target with a known ligand; design a PROTAC with E3 recruiter and linker rationale; propose ternary-complex modelling and a degradation assay plan.

Deliverable: Design report with structures, linker SAR plan and assay cascade

Milestones

  • Ship one original mini-analysis on a public dataset with clearly stated hypothesis and limitations
  • Engage with the TPD Summit and chemical-biology community (post a question, answer one, or share a notebook)
  • Get peer feedback on at least one project and iterate
Citation · documentation
ICH Guidelines
ICH
Why: Category match (Pharma & Biotech R&D)
4

Phase 4 — Portfolio & career launch

3–5 weeks 30–50 hours

Package your work, target real roles, and prepare to interview in the sector.

Prerequisites

  • Phase 3 capstone project shipped
  • 2+ public repos under version control

Skills you'll build

Technical CVPortfolio siteInterview prep (case studies + technical questions)Networking

Hands-on projects

Job-ready portfolio package

Curate 2–3 of your strongest sector projects into a portfolio site with clear case-study writeups, plus a 1-page CV tailored to the target role.

Deliverable: Live portfolio URL + PDF CV + cover letter template

Milestones

  • Publish a portfolio site or pinned GitHub README linking to 2–3 projects
  • Tailor CV to 3 real job ads in the sector and submit applications
  • Practice 5 mock technical interviews with sector-specific case studies
Citation · training
Benchling Academy
Benchling
Why: Category match (Pharma & Biotech R&D)

Curated learning resources

Verified, canonical resources from the official providers in this sector. The AI roadmap builder draws from this same library when it personalizes your roadmap.

Courses

Coursera · Drug Development Product Management
UC San Diego
Python for Everybody
Coursera · Univ. of Michigan
LinkedIn Learning paths
LinkedIn

Trainings

FDA Learn portal
U.S. FDA
Benchling Academy
Benchling
Software Carpentry lessons
The Carpentries
Kaggle Learn
Kaggle

Documentations

ICH Guidelines
ICH
Git & GitHub fundamentals
GitHub Docs

Books

R for Data Science (2e)
Hadley Wickham et al.

Communitys

AAPS membership & resources
AAPS

Typical career paths

Degrader Design Chemist

Designs and synthesises PROTACs and molecular glues for new targets.

Chemical Biologist (TPD)

Validates ternary complexes, degradation kinetics and selectivity in cells.

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